Cold Open, Hollywood, California, 1944. Lupe Velez commits suicide by overdosing on pills. In her final desperate moments, she ignores the warning of the Virgen de Almas Olvidadas and summons the evil spirit of Bloody Maria who traps Lupe’s spirit in an enchanted mirror.
Modern day East L.A., leader of Las Chivas and the baddest Chola around, La Loca, discovers rival gang leader, Baby Dreamer (leader of Las Niñas), macking on her man, Lil Sleeps. The two get into a fight at their Catholic school and get sent to the Sister Superior, Sister Cara-De-Pocos-Amigos. After Sister Cara doles out some punishment, they break out into another fight, knock the Sister unconscious and crack the enchanted mirror, summoning Bloody Maria, who curses them! They see demonic versions of themselves in the mirror which sends them screaming into the halls. After the girls flee, a haunting and decomposing Lupe Velez crawls out of the cracked mirror and prowls the Catholic school.